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Jiaua (Jay) Xie, Ph.D.

Jiaua Xie
Dr. Jiaua Xie, Professor of Pharmaceutical Sciences

Associate Professor of Pharmaceutical Sciences, College of Arts and Sciences, BRITE

North Carolina Central University (NCCU)

Contact: jxie@nccu.edu or 919-530-6705

Education & Training

  • Post-doctoral fellow in Genetics (1998-2000), NC State University, Raleigh, NC
  • Ph.D. in Biophysics (1996), Zhejiang University (former Zhejiang Agricultural University), Hangzhou, China
  • B.S. in Agronomy (1986), Zhejiang University (former Zhejiang Agricultural University), Hangzhou, China

Current Research Projects

  • N-Glycoengineering of tobacco plants to produce cytoprotective asialoerythropoietin (asialo-EPO) and therapeutic glycoproteins
  • Studying the functions of plant-produced therapeutic glycoproteins
  • Using variegated 'Pothos' (Epipremnum aureum) plants to study chloroplast biogenesis
  • Understanding the role of recycling methyl groups (one-carbon units) from alkaloids for plant primary metabolism and growth

Research Capabilities

  • Gene cloning and functional characterization with modern molecular techniques.
  • Agrobacterium-mediated plant transformation.
  • Protein purification from transgenic leaf tissues.
  • Cell-based cytoprotective assay in various cell models.


(*: graduate student;**: undergraduate student; †: corresponding author)

1)      Li FF, Wang WD, Zhao N, Xiao BG, Cao PJ, Wu XF, Ye CY, Shen EH, Qiu J, Zhu Q-H, Xie JH, Zhou XP, Fan LJ. (2015) Regulation of nicotine biosynthesis by endogenous target mimicry of miRNA in tobacco. Plant Physiol. 169: 1062-1071.

2)      Kittur FS, Arthur E*, Nguyen M**, Hung C-Y, Sane DC, Xie JH (2015) Two-step purification procedure for recombinant human asialoerythropoietin expressed in transgenic plants. Int. J. Biol. Macromolec. 72: 1111-1116.

3)      Kittur FS, Lalgondar M, Hung C-Y, Sane DC, Xie JH (2015) C-Terminally fused affinity Strep-tag II is removed by proteolysis from recombinant human erythropoietin expressed in transgenic tobacco plants. Plant Cell Rep. 34: 507-516.

4)      Vallentine P, Hung C-Y, Xie JH, Van Hoewyk D (2014) The ubiquitin-proteasome pathway protects Chlamydomonas reinhardti against selenite toxicity, but is impaired as mitochondrial superoxide accumulates. AoB PLANTS 6: plu062.

5)      Qiu J, Wang Y, Wu SL, Wang YY, Ye CY, Bai XF, Li ZF, Yan CH, Wang ZQ, Shu QY, Xie JH, Lee SH, Fan LJ (2014) Genome re-sequencing of semi-wild soybean reveals a complex Soja population structure and deep introgression. PLoS One 9: e108479.

6)      Hung C-Y, Umsteada ML**, Chen JJ, Holliday BM**, Kittura FS, Henny RJ, Burkey KO, Xie JH (2014) Differential expression of a novel gene EaF82a in green and yellow sectors of variegated Epipremnum aureum leaves is related to uneven distribution of auxin. Physiol. Plant. 152: 749-762..

7)      Zhu CS, Miao GP, Huo YB, Zhang X, Xie JH, Juntao Feng (2014) Establishment of Tripterygium wilfordii Hook.f. hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine. J. Microbiol. Biotechnol. 24(6), 823-834.

8)      Tetteh AY, Sun KH**, Hung C-Y, Kittur FS, Ibeanu GC, Williams D, Xie JH (2014) Genome-wide investigation of selenite-responsive genes in Escherichia coli K12 under toxic and beneficial selenite conditions. Int. J. Microbiol. 2014: 394835.

9)      Kittur FS, Bah M*, Archer-Hartmann S, Hung C-Y, Azadi P, Ishihara M, Sane DC, Xie JH (2013) Cytoprotective effect of recombinant human erythropoietin produced in transgenic tobacco plants. PLoS One 8(10): e76468.

10)  Dewey RE, Xie JH (2013) Molecular Genetics of Alkaloid Biosynthesis in Nicotiana tabacum. Phytochemistry 94: 10-27. 

11)  Zhao JT, Li ZT, Cui J, Henny RJ, Gray DJ, Xie JH, Chen JJ (2013) Efficient somatic embryogenesis and Agrobacterium-mediated transformation of pothos (Epipremnum aureum) ‘Jade’. Plant Cell Tiss. Organ Cult. 114: 237-247.

12)  Hung C-Y, Fan LJ, Kittur FS, Sun K, Qiu J, Tang S, Holliday MB**, Xiao BG, Burkey KO, Bush LP, Conkling MA, Roje S, Xie JH (2013) Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation. Plant Physiol. 161:1049-1060.

13)  Hung C-Y, Holliday MB**, Kaur H*, Yadav R*, Kittur FS, Xie JH (2012) Identification and characterization of selenate- and selenite-responsive genes in a Se-hyperaccumulator Astragalus racemosu. Mol. Biol. Rep. 39: 7635-7645.

14)  Kittur FS, Hung C-Y, Darlington DE**, Sane DC, Xie JH (2012) N-Glycoengineering of tobacco plants to produce cytoprotective asialoerythropoietin. Plant Cell Rep. 31:1233-1243.

15)  Zhao JT, Zhang Q, Xie JH, Hung C-Y, Cui J, Henny RJ, Chen JJ (2012) Plant regeneration via direct somatic embryogenesis from leaf and petiole explants of Epipremnum aureum ‘Marble Queen’. Acta Physiol. Plant. 34: 1461-1469.

16)  Tang S, Wang Y, Li ZF, Gui YJ, Xiao BG, Xie JH, Zhu QH, Fan LJ (2012) Identification of wounding and topping responsive small RNAs in tobacco (Nicotiana tabacum). BMC Plant Bio. 12: 28.

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